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The observation in this study in hepatocytes that protein-SSG formation by either GSSG accumulation or treatment with a direct S -glutathionylation induction agent resulted in IKK--SSG formation, leading to its suppression, was supported by a previous study reporting that S -glutathionylation was associated with suppressed IKK- activity in epithelial cells 41

People who have a genetic predisposition for lower GSH production have an even greater challenge maintaining sufficient GSH

Glutathione protects mitochondria from free radicals and oxidative damage and is, therefore, essential for energy production in the body

10.13633/j.cnki.zjtcm.2019.05.020 96 KalaitzoglouE.FowlkesJ

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