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Description

Emodin decreases GSH content, xCT and GPX4 expression, increases ROS generation, MDA, and lipid peroxidation, effects reversed by ferroptosis inhibitors and autophagy inhibitors, iron chelator DFO, ferostatin-1, and NCOA4 silencing

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used the highest prophylactic MT dose (80 mg/kg) that did not produce any signs of toxicity in mice in their 2021 study (Labban et al

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