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11 It has been suggested that perhaps the role of the innate immune system, as mediated by the natural killer (NK) and natural killer T cells (NKT) which are abundant in hepatocytes, is to cause the release of pro-inflammatory cytokines and chemokines that enhance hepatocellular cytotoxicity

From there, it can be absorbed into the bloodstream, contributing to systemic levels as well

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Senescence limits fibrosis 2 and cancer initiation 3 , maintains normal tissue function 4 and contributes to the outcome of many anticancer therapies 5,6