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Methionine and choline play vital roles in fat metabolism: they help the liver break down fats more efficiently and prevent accumulation of fat in the liver

Without NADPH, glutathione remains in an oxidized state and cannot detoxify free radicals

Targeting the ATF4-dependent autophagy pathway could offer a therapeutic approach for patients with Fms-like tyrosine kinase 3 (FLT3) mutations, as Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) expression increases basal autophagy, which is essential for AML cell survival (40)

doi: 10.1002/ibra.12001 92 MadrigalJLFeinsteinDLDello RussoC