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In this study of FM/chronic fatigue syndrome, patients who were good responders were found to be using a higher and more frequent doses of vitamin B12 for a longer period [17]

For the proper delivery of the drug encapsulated in the liposome, it is imperative to take into consideration the properties of both the stratum corneum and the drug, while considering the site of application, body temperature, and the blood flow of the skin

For example, some MIC B12 (Methionine, Inositol, Choline + B12) blends are more sensitive to temperature and should be refrigerated both before and after first use

doi: 10.1016/j.pharep.2014.04.009

E., De Moudt, S., De Keulenaer, G