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Any disruption to this systembe it through poor diet, environmental toxins, or stresscan throw a wrench in the works, leading to a cascade of health issues

10.1016/B978-0-323-90219-9.00011-X 10 CuevasantaE.LangeM.BonanataJ.CoitioE

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The orbitofrontal cortex shares connections with limbic system, amygdala (extensive reciprocal connections), and direct and indirect connections with the hypothalamus

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