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Disclosures: Michael Vinikoor: Abbott Diagnostics: Speaking and Teaching, Chipo Chitambi: Nothing to Disclose, Anjali Sharma: Nothing to Disclose, Caleb Figge: Nothing to Disclose, Samuel Bosomprah: Nothing to Disclose, Saphira Munthali -Mulemba: Nothing to Disclose, Tukiya Kanguya: Nothing to Disclose, Kim Watson: Nothing to Disclose, Kelvin Kalaba: Nothing to Disclose, David Mwanza: Nothing to Disclose, Ellen Eaton: Gilead Foundation: Patient Engagement Working Group, Laura Murray: Nothing to Disclose, Karen Cropsey: Nothing to Disclose, Jeremy Kane: Nothing to Disclose 1539 THERAPEUTIC INHIBITION OF BRUTON'S TYROSINE KINASE (BTK) ACTS ON BOTH IMMUNE CELLS AND HEPATOCYTES TO ATTENUATE IMMUNE CELL ACTIVATION AND STEATOSIS IN A MOUSE MODEL OF ALCOHOL-ASSOCIATED HEPATITIS Prashanth Thevkar Nagesh 1 Yuan Zhuang 2 Mrigya Babuta 2 Marti Ortega-Ribera 2 the AlcHepNet clinical investigators 2 Gyongyi Szabo 3 , 1 Beth Israel Medical Center, 2 BIDMC Harvard Medical School, 3 Beth Israel Deaconess Medical Center Background: Alcohol- associated hepatitis (AH) involves hepatic steatosis, neutrophil infiltration, neutrophil extracellular traps (NETs) formation and NLRP3 inflammasome activation in macrophages

One critical difference between the two formats: reconstituted solutions typically remain stable for 28 days when refrigerated at 2-8 degrees Celsius (35.6-46.4 degrees Fahrenheit)

Am J Hematol, 2026

Autophagy-Related Gene 12 (ATG12) is a Novel Determinant of Primary Resistance to HER2-Targeted Therapies: Utility of Transcriptome Analysis of the Autophagy Interactome to Guide Breast Cancer Treatment

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