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In larger amounts, its highly acidic nature can irritate the throat and digestive system, interfere with insulin, and potentially cause a potassium deficiency

This can be attributed to two different peptide inserts representing 174196 and 443480 amino acids (numbers represent the positions in Pf GS) spanning across the regions that are not directly associated with the substrate-binding and catalytic sites

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Interestingly, S100A15 is different from other S100 proteins because of its lack of acidic amino acids and the increased basic amino acids in the C-terminal (167)

The extensive cross-talk between liver cell types during NASH pathogenesis and progression underscores the importance of targeting multiple aspects of liver physiology and pathophysiology in treating this complex disease