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Collectively, GGCT functions as a metabolic rheostat that orchestrates mitochondrial homeostasis through diverting Gln flux toward glutathione biosynthesis to fortify redox defense, while enhancing Glc-fueled TCA cycle anaplerosis to sustain cell proliferation

[3] The glycine cleavage system differs from the other complexes, and has a different nomenclature

Nature 448 , 474479 (2007)

Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

Overall, GA was absorbed through the gastrointestinal tract, primarily distributed in the kidneys, then metabolized in the liver, and excreted by the kidneys