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These findings suggest that rhIL-7 therapy can potentiate and broaden immune responses, particularly in individuals with limited nave T cell populations and reduced TCR repertoire diversity, such as those experiencing advanced age, HIV infection, or iatrogenic (chemotherapy-induced) lymphodepletion

instead, it transitions into a state of persistent, unremitting chronic inflammation

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170 Emerging evidence implies a role for CBS in the resistance of cancer cells to ferroptosis, 85,171 although the mechanistic details of this observation remain to be unravelled (detailed below)