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"They're not based on human models." In an email to CBC News, he stated he was candid with his patients about the current research regarding BPC-157

This decline creates several problems: Low NAD+ leads to reduced DNA repair capacity and more DNA damage Decreased NAD+ hurts mitochondrial fatty acid -oxidation and oxidative phosphorylation NAD+ depletion affects all hallmarks of aging The good news is that restoring NAD+ has shown great results in preclinical studies