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In studies of non-alcoholic fatty liver disease, RSV was found to decrease the expression of lipogenic genes and triglyceride levels by attenuating NRF2 promoter methylation induced by high-fat diets and high glucose treatments, while also modulating NRF2 signaling pathways [153]

3301-A ALCOHOL AND THE LIVER PHENOTYPE OF ADULTS WITH ALPHA-1 ANTITRYPSIN DEFICIENCY Malin Fromme 1 , Carolin Victoria Schneider 2 , Nurdan Guldiken 1 , Samira Amzou 1 , Yizhao Luo 1 , Monica Pons 3 , Joan Genesca 3 , Marc Miravitlles 4 , Katrine Holtz Thorhauge 5 , Johan Waern 6 , Kai M

( 10.1093/humrep/dew208) [DOI] [PubMed] [Google Scholar] De Vos M, Grynberg M, Ho TM, et al

Finally, two studies reported that genetic variability in CD44 antigen might predispose patients to acetaminophen-induced liver injury at supra-therapeutic doses [106] or to acute liver failure after the drug overdose [100]