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After its nuclear translocation, the MIF nuclease activity induces DNA damage to promote neuronal cell death

AICART: aminoimidazolecarboxamide ribonucleotide transferase BHMT: betaine-homocysteine methyltransferase CBS: cystathionine -synthase CTGL: -cystathionase DHFR: dihydrofolate reductase DMGD: dimethylglycine dehydrogenase DNMT: DNA-methyltransferase FTD: 10-formyltetrahydrofolate dehydrogenase FTS: 10-formyltetrahydrofolate synthase GCS: -glutamylcysteine synthetase GDC: glycine decarboxylase (glycine cleavage system) GNMT: glycine N-methyltransferase GPX: glutathione peroxidase GR: glutathione reductase GS: glutathione synthetase MAT-I: methionine adenosyl transferase I MAT-III: methionine adenosyl transferase III MS: methionine synthase MTCH: 5,10-methenyltetrahydrofolate cyclohydrolase MTD: 5,10-methylenetetrahydrofolate dehydrogenase MTHFR: 5,10-methylenetetrahydrofolate reductase NE: non-enzymatic conversion PGT: Phosphoribosyl glycinamidetransformalase SAAH: S-adenosylhomocysteine hydrolase SDH: sarcosine dehydrogenase SHMT: serinehydroxymethyltransferase TS: thymidylate synthase Metabolites

[DOI] [PMC free article] [PubMed] [Google Scholar] 380.Yakhine-Diop SMS, et al

When your body can efficiently manage blood sugar and burn fat, it is much easier to maintain a healthy weight and consistent energy levels throughout the day

doi: 10.3390/biom10010054 58 MustafaG.SakataK.HossainZ.KomatsuS