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Furthermore, persistent activation of the TCR and the type I IFN- signalling triggered mitochondrial changes via increasing NAD + consumption due to both CD38 overexpression and PARP activation in CD8 + T cells, resulting in lower spare respiratory capacity, decreased bioenergetic fitness and thus increased tendency to die

In the cytosol and nucleus, several enzymes create localized ROS microdomains: xanthine oxidoreductase (interconverting XDH and XO) at cytosolic and endothelial surfaces, monoamine oxidases on the outer mitochondrial membrane facing the cytosol, dihydrolipoamide dehydrogenase within the PDH/OGDH complexes and NOX isoforms positioned at the nuclear envelope (Moloney et al

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