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avg body weight lost with Semaglutide (NEJM STEP 1 trial, 68 weeks) 2025% avg body weight lost with Tirzepatide (SURMOUNT-1, 7288 weeks) of semaglutide patients lost 5% of body weight (STEP 1 trial)of semaglutide patients lost 5% of body weight (STEP 1 trial) Week 14: Appetite reduction, smaller portions naturally Month 13: Steady fat loss begins, 12 lbs/week avg Month 36: Visible body composition change, reduced visceral fat 68 weeks: Average 14.9% total body weight reduction Ozempic for weight loss and Wegovy for weight loss produce comparable outcomes at equivalent doses

Comment: At the August 25, 2025 HOP Panel Meeting, the presenter advised the panel to request that CMS assign CPT code 0786T to APC 5464 (Level 4 Neurostimulator and Related Procedures)

It is indicated for people who are obese, and who have failed to lose enough weight with diet and exercise alone not for people who want to lose just a few pounds

Sample collection Fresh fecal samples were collected daily or every 2nd day postinfection directly in 1 ml of sterile 1 PBS for plating

The extensive safety database across multiple clinical trials and animal toxicology studies provides reassurance about AOD-9604s tolerability and absence of serious adverse effects