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At the same time, if we were to discount the clinical labor times too heavily by overapplying the MPPR, we run the risk of under-allocating sufficient clinical labor to cover the typical case, which could result in the safety issues identified by the commenters

For children, Walsh modified his formula taking into account B12 absorption amounts found in children by Hjelt and Krasilnikoff (Hjelt, 1986)

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Low B12 disrupts myelin synthesis, the protective sheath around nerves, leading to tingling, numbness, or a pins-and-needles sensation in the hands and feet

Clin Vaccine Immunol 17:19521957