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High doses are given to increase intestinal concentration, allowing enough B12 absorption to meet the body's needs

2012 GHK-Cu may prevent oxidative stress in skin by regulating copper and modifying expression of numerous antioxidant genes Cosmetics Study demonstrating GHK-Cu's regulation of antioxidant gene expression and copper-dependent protective mechanisms in skin tissue

If you are experiencing a feeling of pins and needles or numbness in the ankle or foot, during or post exertion you maybe a candidate for a B12 injection

Source: Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia (2016) Remarkable improvements with B12 and folinic acid treatment

First, its role as a collagen synthesis co-factor directly supports the production and maintenance of the dermal collagen that gives skin its firmness, elasticity and structural quality