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But when they build up faster than your body can neutralise them, it causes oxidative stress - basically, internal rusting

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however, its uptake by the neuronal tissue should be strictly regulated to prevent toxicity (Linert and Kozlowski, 2012

supporting the feasibility of treat-smart personalized therapy rather than non-specific escalation

Along these lines, an emerging theory linking excitotoxicity and mitochondrial dysfunction suggests that an accumulation of lactate, a metabolic byproduct which is toxic (especially to nerve cells) at high concentrations may play a role in ALS progression (Vadakkadath Meethal 2012)