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(136) confirmed in 2022 that amino acid metabolism plays an important role in DKD progression

For instance, high mutation rates in CREBBP/EP300 may regulate NK cell activating receptor (e.g., NKG2D) expression (119, 120)

In such cases, cautious use of potassium is generally recommended because the hypokalemia does not reflect potassium deficiency but rather transcellular potassium redistribution