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(137), at baseline, IL6 is secreted in a biphasic circadian pattern, with two nadirs at 08.00 and 21.00 h and two zeniths at about 19.0020.00 and 04.0005.00 h, with the stronger peak at 05.00 h (Figure 5)

However, clinical trials in humans have demonstrated mixed results

For example, case control studies using the National Birth Defects Prevention Database to investigate neural or cardiac birth defects in babies whose mothers had been occupationally exposed to PAHs found some evidence of an association of PAH exposure with spina bifida but not other neural tube defects, and not with congenital heart disease (Langlois et al., 2012

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