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COX-2 inhibitors reduce inflammation by blocking the cyclooxygenase-2 enzyme, which is involved in the synthesis of pro-inflammatory prostaglandins

Oxid Med Cell Longev 2020:6286984 Li X et al (2021) A-lipoic acid alleviates folic acid-induced renal damage through inhibition of ferroptosis

In the ensuing years the off label use of biologic agents increased

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