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Santambrogio et al., 2019

Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling

Most patients notice improvement over several weeks, with full benefits often appearing over two to three months

Transcriptionally, OPA1 is controlled by factors such as PGC-1, TFAM, NF-B, and signal transducer and activator of transcription 3 (STAT3) in response to metabolic and inflammatory signals