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Abnormalities in white matter have also been reported in preterm infants and microstructural changes on MRI could be related to neurological disability in later life (39)

As such, while preclinical evidence supports the hypothesis that exercise can regulate oxidative stress and HPA axis function, the extent to which these findings can be generalized to human populations is still waiting to be investigated

As of early 2026, multiple Phase 3 trials have reported positive topline results, regulatory submissions have been filed, and the FDA is reviewing orforglipron for an obesity indication with a target action date of April 10, 2026

First strand cDNA was synthesized with 1 g of RNA and oligo(dTs) to a final volume of 20 L according to the manufacturers instruction (Thermo Scientific, USA)

JCI Insight 2:e90133