how does glutathione s-transferase cause drug resistance in cancer cells

how does glutathione s-transferase cause drug resistance in cancer cells transferases: substrates, inihibitors and pro-drugs and neurodegenerative diseases Frontiers | Glutamine's double-edged sword:

Name: how does glutathione s-transferase cause drug resistance in cancer cells transferases: substrates, inihibitors and pro-drugs and neurodegenerative diseases Frontiers | Glutamine's double-edged sword:
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Frontiers Glutamine's double edged sword: fueling tumor growth and offering therapeutic hope Frontiers Modulation of redox homeostasis: A strategy to overcome cancer drug resistance Frontiers Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches Cancer drug resistance: an evolving paradigm Nature Reviews Cancer Unveiling the mechanisms and challenges of cancer drug resistance Cell Communication and Signaling Springer Nature Link

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doi: 10.1016/j.cmet.2005.01.003 40

Soluble GSTs consist of two subunits (25 kDa), which are divided into two domains: the N-terminal / forming the G region and the -helical forming most of the H region, which is responsible for the binding of the electrophilic substrate