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Concerning the ApoE4 variant, regardless of AD diagnosis, older adults that are ApoE4 + display a greater level of A accumulation that is not evident in ApoE3 + or ApoE2 + individuals (Lim et al., 2017), and AD patients with the ApoE4 genotype ( +/+ or +/ ) display higher levels of intraneuronal A accumulation compared to controls, indicating a baseline detrimental cognitive effect (Yamazaki et al., 2019)

Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study

Food and Drug Administration (FDA)-approved aldehyde dehydrogenase (ALDH) inhibitor traditionally used for alcohol dependence, has garnered significant attention in recent years for its potential as a copper ionophore in anticancer therapy [258,259,260,261]

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Additionally, flow cytometry was performed to detect the fluorescence intensity of treated senescent cells