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The first major discovery happened in the mid-20th century by Dr

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doi: 10.1172/JCI19246 32 CintiSMitchellGBarbatelliGMuranoICeresiEFaloiaEet al

Cell penetration is not bloodbrain-barrier penetration A peptide entering a cultured cell under controlled laboratory conditions does not prove that an oral, nasal or injected product reaches the human brain intact