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46 When extended-release naltrexone versus buprenorphine in combination with naloxone was studied for relapse prevention in OUD, 47 treatment with the buprenorphine naloxone or long-acting injectable antagonist naltrexone (XR-NTX) produced a similar decreased risk of relapse in those with an OUD who inject opioids

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N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential

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Inositol trisphosphate (IP 3 )/Ca 2+ signaling in astrocytes controls theta rhythm and REM sleep, and genetically lowering IP 3 levels in astrocytes was reported to solely affect REM sleep (Foley et al., 2017)