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The observation that the number of mitochondria entering cells is small yet the effects are rapid suggests the existence of a non-internalization mechanism, where mitochondria may not need to enter cells to exert their effects (186)

"We don't see any indications of this in the muscles at the moment," Van Vugt noted

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UQCRC1 is a newly identified PD-causing gene that is clinically characterized by autosomal dominant late-onset parkinsonism with polyneuropathy ( UQCRC1 encodes the mitochondrial ubiquinol-cyt c reductase core protein 1 (UQCRC1), which is a core subunit of cIII

In conclusion, nearly four decades after its initial discovery 14 , a family of BGCs involved in the biosynthesis of 1 and related compounds has been characterized