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DSIP has more human data, but that data is old, inconsistent, and methodologically limited

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Although randomized controlled trials are still needed, clinical experience points to a promising therapeutic horizon for women with lipedema, through a transdisciplinary approach that integrates pharmacological treatment, physiotherapy and exercise, nutritional therapy, psychological support, and aesthetic or surgical procedures.37,39 Long-term use of diuretics is discouraged because they do not address the underlying inflammatory processes

These studies have shown that a greater proportion of users of sunless tanning are female, although this varies by location, additionally the values for the percentage of female users have ranged between 63% and 95%