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Biophys J 68(3):10271044 Chauveau C, Bonnemann CG, Julien C, Kho AL, Marks H, Talim B, Maury P, Arne-Bes MC, Uro-Coste E, Alexandrovich A, Vihola A, Schafer S, Kaufmann B, Medne L, Hbner N, Foley AR, Santi M, Udd B, Topaloglu H, Moore SA, Gotthardt M, Samuels ME, Gautel M, Ferreiro A (2014) Recessive TTN truncating mutations define novel forms of core myopathy with heart disease

Peak plasma concentrations after standard oral doses are in the low nanomolar range (typically 550 nM), far below the micromolar concentrations (150 M) used in most in vitro studies (165, 166)

Emollients work by creating a barrier to trap moisture in

[38, 39, 40, 41] This approach produces neutralizing antibodies (nAbs) against these proinflammatory biomolecules to inhibit their activities

The UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is a 79-kDa key bifunctional enzyme of sialic acid biosynthesis that consists of N-terminal epimerase and C-terminal kinase domains 2