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The primary clinical concern associated with the systemic injection of GHK-Cu is the forced introduction of exogenous copper directly into the bloodstream

concluded that fenofibrate can inhibit ferroptosis to improve diabetic retinopathy, but did not measure iron-related indices closely associated with ferroptosis, such as iron levels, GPX4, and SLC7A11, indicating that the results require further confirmation [174]

The use of chemicals and antimicrobials leads to the generation of toxic antibiotic residues or chemicals or derivatives emerging from the chemicals

However, the addition of exogenous CoQ10 was not found to alleviate ferroptosis in FSP1-deficient cells, indicating that exogenous CoQ10 does not directly affect ferroptosis but rather regulates it indirectly through endogenous CoQ10

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