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2 Importantly, they also showed that pharmacologically inhibiting all other known cell death pathwaysincluding necroptosis (with necrostatin-1), ferroptosis (with ferrostatin-1), oxidative stress (with N-acetyl cysteine), and apoptosis (with Z-VAD-FMK)failed to suppress elesclomol-induced cell death

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To reduce the collinearity across variables and number of features used for cluster analysis while retaining the majority of variance, we normalized the variables by converting raw scores to z -scores and applied principal component analysis (PCA, 23