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Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C- on insulin action in skeletal muscle cells

MATERIALS AND METHODS Animals Male Albino Wistar (200 g) rats, were used in all of the experiments approved by the Local Ethic Committee (at least 10 rats per each experimental group per each period), assessed by observers naive about the given treatment

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the same dose of 20 mg can be tried for 72 hrs or higher for 1- 3 times a week application

J Immunol (2001) 167(12):7094101