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Furthermore, the high sequence identity of the Chi corresponding proteins found in B

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It is noteworthy that pre-mutation carriers often develop a neurodegenerative disorder called the Fragile X-associated Tremor/Ataxia Syndrome (FXTAS, Figure 2), which presents with neurodegeneration, parkinsonism and brain atrophy, and which is associated with primary ovarian insufficiency in females (reviewed in Botta-Orfila et al., 2016