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The short plasma half-life of GHK-Cu is one reason why twice-daily dosing schedules are sometimes used in injectable protocols, though the peptide's downstream gene expression effects appear to persist well beyond its plasma clearance

S-adenosylmethionine (SAMe), an amino acid derivative important in liver metabolism, and extracts from milk thistle ( Silybum marianum ), have been investigated (alone and in combination) in dogs for their liver-protecting properties and are currently used as part of treatment for a variety of liver diseases in dogs

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Delcour et al

& Collier, J