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Anelli, T., Sannino, S

The intrinsic MOMP-associated apoptotic pathway is tightly regulated by the Bcl-2 family of proteins comprising anti-apoptotic Bcl-2, Bcl-XL, Bcl-W, pro-apoptotic effector Bax and Bak proteins, and BH3-only proteins, including Bad, Bim, PUMA, and Bid (modulating apoptosis through antagonizing anti-apoptotic Bcl-2 or inducing the activity of Bax or Bak) [80, 259, 260]

These Trojan horse NPs not only reduce toxicity risks associated with non-specific distribution but also enhance the anti-AS efficacy of RAP

However, emerging evidence indicated that ferroptosis is an autophagic cell death process 48,49,50

For decades, the prevailing models have been shaped by the paradigm of genetic determinism, which attributes acquired resistance primarily to fixed genomic alterations arising from stochastic DNA mutations [2, 3]