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*Correspondence: Weina Li, [email protected] Meng Li, [email protected] These authors have contributed equally to this work This article was submitted to Drug Metabolism and Transport, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Sublingual delivery itself is a well-established pharmaceutical route used for many medications, including nitroglycerin, certain vitamins, and hormone preparations

This small but remarkably powerful molecule consists of three amino acids (glycine, histidine, and lysine) complexed with a copper ion

Glycyl-L-histidyl-L-lysine, the human tripeptide that Loren Pickart isolated from plasma and characterized in Nature New Biology in 1973, weighs 340.4 daltons 17

As we age, the body produces less collagen and elastinkey proteins responsible for skin firmness and elasticity