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showed that Gstm1 KO mice displayed augmented kidney injury and inflammation, compared to wild-type mice

Weight loss was accompanied by improvements in cardiometabolic parameters, including a decrease in systolic blood pressure (-9.9 mmHg) and waist circumference (-17.5 cm) (placebo-adjusted: 6.7 mmHg and 13.5 cm, respectively)

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BaP acts through suppressing the Nrf2/HO-1 pathway, resulting in a significant reduction of the antioxidant enzyme activities and a marked elevation of lipid peroxidation, cortisol, and proinflammatory cytokine levels, which subsequently lead to notable pathological changes in the hepatic, branchial, and intestinal tissues

in fact a comparison between e-GST and e-CAT activities shows completely different species profiles (Figure 1)