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Nebulization administration results in antibody concentrations in broncho alveolar lavages (BAL) more than 10 times higher than the IV route 48 hours posttreatment and a systemic passage resulting in serum concentrations 100 times lower than the IV route

When AMPK is phosphorylated, it shifts cells toward energy conservation by inhibiting mTORC1 and stimulating fat breakdown and glucose uptake (86)

The newly synthesized p62 protein further binds to and inhibits Keap1, thereby amplifying the NRF2 signaling pathway (49)

Genetic inhibition of GCLC enhances ferroptosis due to metabolic stress, including cystine starvation (Gao et al., 2015).GCL links cysteine and Glu to produce -glutamylcysteine (-GC) which is catalyzed to G-SH by GSS