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These include constrained tissue sizes, difficulty in cell retrieval for downstream analysis, and, most critically, a limited volume of effluent for comprehensive molecular profiling (e.g., proteomics, metabolomics), which is essential for biomarker discovery and mechanistic studies (215218)

[DOI] [PubMed] [Google Scholar] 137.Gan J., Ruan Q., He B., Zhu M., Shyu W.C., Humphreys W.G

Magnetic resonance spectroscopy Brain MRS PgACC/dACC/muscle data were available, respectively, for 24/23/21 ME/CFS patients, 21/17/22 long COVID patients and 24/22/23 HCs

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However, this approach, which typically examines single-target mechanisms, diverges from the holistic and complex nature of TCM