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PARK2+E mice had significantly lower expression of Cpt1a (0.73 0.03 SEM), Cpt1c (0.86 0.02 SEM), Nrf2 (0.78 0.07 SEM), Pgc1 (0.82 0.3 SEM), Iba1 (0.85 0.3 SEM) and Gfap (0.84 0.03 SEM) compared to PARK2+V ( Cpt1a 1 0.05 SEM, p = 0.004, Cpt1c 1 0.04 SEM, p = 0.04, Nrf2 1 0.5 SEM, p = 0.03, Pgc1 1 0.4 SEM, p = 0.01, Iba1 1 0.05 SEM, p = 0.03, Gfap 1 0.5 SEM, p = 0.04) (Fig