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All gastrointestinal disorder events were mild to moderate in severity

DNA will be extracted from soil and plant samples, followed by library preparation and shotgun metagenomic sequencing

Zhu JK (2016) Abiotic stress signaling and responses in plants

For REU scoring system, lesion severity at each site will be assessed by scoring reticular/hyperkeratotic, erosive/erythematous, and ulcerative lesions using specific criteria: Reticular/hyperkeratotic changes will be rated as 0 (absence of white striations) or 1 (presence of white striations or keratotic papules)

Uniform manifold approximation and projection (UMAP) (64, 65) was used to transform the high-dimensional patient data, encompassing demographic information, symptoms, and comorbidities into a two-dimensional space