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RGN-352 was shown to be safe and well-tolerated with no serious drug-related adverse events reported (PMID: 20536472) Phase 2 AMI trial (incomplete): RegeneRx designed a Phase 2 proof-of-concept trial (NCT01311518) to evaluate RGN-352 in approximately 75 patients with acute ST-segment elevation myocardial infarction (heart attack)

for example, recommending once daily 5-ASA dosing instead of twice daily

It enables compensatory exchange of mtDNA-encoded products and metabolites between organelles, counteracting functional deficits arising from ROS-induced mtDNA mutations