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Furthermore, increased number of hypodense eosinophils was observed in bronchoalveolar lavage eosinophils following an antigen-challenge (Kroegel et al., 1994)

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Traditional antifolate chemotherapeutics have many deleterious side effects due to the importance of folate pathways in healthy proliferating cells and Table 1: Established anti-folate antineoplastic agents (Newman A C and Maddocks O D K, 2017) One-carbon metabolism plays a significant role in References: Kalhan S C