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doi: 10.1016/j.celrep.2021.108771 Summary Keywords childhood cancer, neuroblastoma, combination therapy, oxidative stress, DPI, MitoQ, metabolism Citation Epp S, Egan D, Poon E, Abdul Aziz AA, Wynne K, Chesler L, Halasz M and Kolch W (2025) Oxphos targeting of MYCN -amplified neuroblastoma

HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium

recommended daily allowance (RDA) is: 2.4 micrograms (mcg) per day Certain groups may require higher intake, including: Pregnant women: 2.6 mcg daily Breastfeeding women: 2.8 mcg daily Older adults Vegetarians and vegans Individuals with absorption issues 500 mcg to 5000 mcg , which is significantly higher than the RDA but still generally considered safe when medically supervised

However, some symptoms are more noticeable, such as memory issues, difficulty maintaining your balance, mouth ulcers, a sore, swollen tongue, and heart palpitations