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A patient with impaired absorption can maintain a borderline-normal serum level for a long time while their cellular B12 is progressively inadequate

Notably, a significant portion of albumin in the blood lacks the C-terminal L585 residue, ranging from 3 to 15% in healthy individuals and up to 93% in patients with pancreatitis or other pancreatic disorders 60,61,62

Fortunately, these patients usually respond to more intense treatments

Aberrant apoptotic machinery confers melanoma dual resistance to BRAF(V600E) inhibitor and immune effector cells: immunosensitization by a histone deacetylase inhibitor

Cells were treated with IL-1 for 24 hours throughout the whole study unless otherwise stated