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While traditionally viewed as a stable lineage committed to immunosuppression, emerging evidence indicates that certain Treg subsets can acquire effector-like characteristics under inflammatory conditions, including the production of pro-inflammatory cytokines

For those with autoimmune disorders , stimulating the immune system might not always be advisable

Conclusions The versatility of oxidative stress occurrence in response to environmental conditions, like extreme temperatures, drought, soil salinity, pests, and diseases, highlights the importance for developing crops which are able to withstand various environmental challenges simultaneously

However, including seropositive individuals in phase II and III trials should be promoted to ensure population-wide implementation of the vaccine after registration

L.SinghS