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88 Similarly, IL-13 the T-helper type 2 cytokine and key effector of ulcerative colitis also affects intestinal epithelial cell TJ function as well as apoptosis, 89 and was recently shown to regulate claudin-2 transcription in a signal transducers and activators of transcription-dependent manner

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It also activates key signaling cascades, including PI3K/AKT/GSK-3 and PP2A/MAPKs/HIF-1, to counteract oxidative stress and neuronal death [93, 95]

Teixeira FarinhaHBouriezDGrimaudTRotariuA-MColletDMantziariSet al

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