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These responses occur within half an hour and activate multiple cellular signaling mechanisms, supporting the statement that the cellular response to metal ions and the following signaling pathways are integrated in a signal transduction process [124]

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(iv) increased density of mitochondria and enlarged endoplasmic reticulum in soma and primary processes

Mn was recently found to affect TH expression at a transcriptional level through the downregulation of the RE1-silencing transcription factor (REST) (Pajarillo et al., 2020b)