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Description

Its mechanisms are broad and systemic, meaning it can benefit tissues throughout the body

What type of provider will I see during my visits

While broad acylome remodeling (e.g., hypermalonylation) may have a limited impact under normal conditions, under severe energy stress (e.g., SLC25A3 deletion), SIRT5 function is compromised by acetylation, exacerbating mitochondrial dysfunction in the heart [83, 84]